CASE REPORT
Abstract

Approximately 0.2% of pregnancies are complicated by hyperthyroidism. Graves disease accounts for 90% of these cases. Gestational trophoblastic disease is a rare cause of hyperthyroidism in which high levels of hCG cause activation of the thyrotrophin receptor and stimulate supraphysiological secretion of thyroid hormone. The hCG levels are particularly high at 10–12 weeks gestation, in trophoblastic disease. Some of the patients of hydatidiform mole may exhibit signs of hyperthyroidism due to high levels of hCG.
We report a case series of four women with gestational trophoblastic disease along with clinical as well as biochemical hyperthyroidism resolving after treatment of GTD.
Key words: hyperthyroidism, Gestational Trophoblastic Diseases, BhCG, hydatidiform

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